HUBUNGAN TINGKAT KEPATUHAN KONSUMSI ANTIRETROVIRUS (ARV) TERHADAP KADAR CD4 PADA PASIEN HIV DI RSUD PROVINSI BANTEN

Abstrak

Antiretroviral (ARV) adalah obat yang menghambat replikasi Human Immunodeficiency Virus (HIV), dan memiliki reseptor cluster of differentiation 4 (CD4) pada bagian permukaan selnya HIV telah menjadi pandemi global Yang memengaruhi berbagai lapisan masyarakat di sekitar orang dengan HIV. Kepatuhan mengonsumsi antiretrovirus dapat menandakan keberhasilan dari program Voluntary Counseling and Testing (VCT) sehingga terjadian peningkatan kadar CD4 yang signifikan. Desain penelitian menggunakan desain penelitian korelasional dengan mengumpulkan data dari pasien HIV di RSUD Banten dengan kadar CD4 kurang dari 200 sel/uI yang sedang menjalani terapi ARV kemudian diukur tingkat kepatuhan pasien tersebut dalam minum obat ARV

Berdasarkan hasil nilai uji korelasi antara kepatuhan dan peningkatan kadar CD4 sesudah pemberian ARV didapatkan nilai korelasi sebsesar 0,574 bernilai positif, menandakan bahwa terdapat hubungan yang kuat antara kedua variable, dimana semakin tinggi kepatuhan maka kadar CD4 semakin tinggi. Adapun nilai signifikansinya sebesar 0,003, menandakan bahwa terdapat hubungan yang signifikan atau berarti antara kepatuhan dan kadar CD4, dimana semakin tinggi kepatuhan maka kadar CD4 semakin tinggi.

Antiretroviral (ARV) is a drug that inhibits the replication of the Human Immunodeficiency Virus (HIV), and has a cluster of differential 4 (CD4) receptor on the surface of its cells. HIV has become a global pandemic that affects various levels of society around people with HIV. Compliance with taking antiretrovirals can indicate the success of the Voluntary Counseling and Testing (VCT) program resulting in a significant increase in CD4 levels.

The research design used a correlational research design by collecting data from HIV patients at Banten District Hospital with CD4 levels of less than 200 cells/uI who were undergoing ARV therapy and then measuring the patient's level of compliance in taking ARV medication.

Based on the results of the correlation test value between compliance and the increase in CD4 levels after giving ARVs, a correlation value of 0.574 was obtained, which is positive, indicating that there is a strong relationship between the two variables, where the higher the compliance, the higher the CD4 levels. Meanwhile, the significance value is 0.003, indicating that there is a significant or meaningful relationship between compliance and CD4 levels, where the higher the compliance, the higher the CD4 levels.