FORMULASI SEDIAAN GEL HAND SANITIZER EKSTRAK ETANOL HERBA RUMPUT TEKI ( Cyperus Rotundus L. ) SEBAGAI ANTI BAKTERI TERHADAP STAPHYLOCOCCUS AUREUS ATCC 25923

Abstrak

Herba rumput teki (Cyperus Rotundus L.) adalah salah satu tanaman yang dapat digunakan sebagai antibakteri. Herba rumput teki (Cyperus Rotundus L.). memiliki kandungan alkaloid, flavanoid, tanin, seskuiterpenoid dan saponin.Tujuan penelitian ini untuk membuktikan bahwa ekstrak herba rumput teki (Cyperus Rotundus L.) mempunyai aktivitas antibakteri terhadap bakteri Staphylococcus Aureus ATCC 25923, untuk membuktikkan bahwa formulasi sediaan hand sanitizer ekstrak herba rumput teki (Cyperus Rotundus L.) mempunyai aktivitas antibakteri, serta membuktikkan bahwa sediaan hand sanitizer ekstrak herba rumput teki (Cyperus Rotundus L.) memiliki mutu fisik yang baik. Penelitian ini dilakukan dengan metode eksperimental. Hasil penelitian menunjukkan bahwa ekstrak herba rumput teki (Cyperus Rotundus L.) mempunyai aktivitas antibakteri terhadap Staphylococcus aureus dengan konsentrasi 3% , 5% dan 7% dengan masing-masing diameter zona hambat 8 mm; 10 mm; 14,16 mm; dan berhasil diformulasikan dalam bentuk sediaan gel hand sanitizer dengan mutu fisik yang baik. Selain itu, formulasi gel hand sanitizer dengan ekstrak herba rumput teki pada kosentrasi 5%, 10% dan 20% memiliki aktivitas antibakteri terhadap Staphylococcus aureus ATCC 25923. Berdasarkan hasil pengujian formulasi optimum sediaan gel hand sanitizer ekstrak herba rumput teki memiliki aktivitas antibakteri terhadap Staphylococcus aureus ATCC 25923 tertinggi yaitu pada konsentrasi 20%.

The herb of puzzle grass (Cyperus rotundus L.) is one of the plants that can be used as an antibacterial. Herb of puzzle grass (Cyperus rotundus L.). It contains alkaloids, flavanoids, tannins, sesquiterpenoids and saponins. The purpose of this study is to prove that the herb extract of Teki grass (Cyperus Rotundus L.) has antibacterial activity against the bacteria Staphylococcus Aureus ATCC 25923, to prove that the formulation of hand sanitizer preparations of Teki grass herb extract (Cyperus Rotundus L.) has antibacterial activity, and to prove that the hand sanitizer preparation of Teki grass herb extract (Cyperus Rotundus L.) has good physical quality. This research was conducted using an experimental method. The results showed that the herb extract of teki grass (Cyperus rotundus L.) had antibacterial activity against Staphylococcus aureus with concentrations of 3%, 5% and 7% with an inhibition zone diameter of 8 mm; 10 mm; 14.16 mm; and successfully formulated in the form of hand sanitizer gel preparations with good physical quality. In addition, the formulation of hand sanitizer gel with teki grass herb extract at concentrations of 5%, 10% and 20% has antibacterial activity against Staphylococcus aureus ATCC 25923. Based on the results of the test of the optimal formulation of hand sanitizer gel preparations, teki grass herb extract has the highest antibacterial activity against Staphylococcus aureus ATCC 25923, which is at a concentration of 20%.